Amphetamine-Linked Priapism Risks

Emergency for amphetamine users

Priapism, a persistent and painful erection lasting more than 4 hours, has been linked to amphetamine misuse. This condition is often associated with the use of stimulant medications, including amphetamines, for attention-deficit/hyperactivity disorder (ADHD) in children.

Risk Factors

• Amphetamine use, particularly in high doses or prolonged periods
• Combination with other medications that can cause priapism, such as antidepressants or antihypertensives
• Underlying medical conditions that increase the risk of priapism, such as sickle cell disease or multiple myeloma

Symptoms

• Persistent and painful erection lasting more than 4 hours
• Lack of sexual stimulation or interest
• Difficulty achieving detumescence (return to flaccid state)
• Possible complications, such as penile ischemia, fibrosis, or erectile dysfunction

Management

• Immediate medical attention is necessary to prevent long-term damage
• Treatment may involve aspiration of blood from the penis, injection of a vasoconstrictor, or surgical shunting
• Discontinuation of amphetamine use and other potentially contributing medications
• Monitoring for potential complications and long-term effects

Prevention

• Educating patients and caregivers about the risks of priapism associated with amphetamine misuse
• Closely monitoring patients for signs and symptoms of priapism
• Avoiding high doses or prolonged use of amphetamines
• Considering alternative treatments for ADHD that are less likely to cause priapism