{"id":4964,"date":"2014-08-19T17:37:03","date_gmt":"2014-08-19T14:37:03","guid":{"rendered":"http:\/\/seragpsych.com\/wordpress\/?p=4964"},"modified":"2014-08-19T17:37:03","modified_gmt":"2014-08-19T14:37:03","slug":"adjunctive-lithium-effective-for-second-generation-antidepressants-tricyclics","status":"publish","type":"post","link":"https:\/\/seragpsych.com\/wordpress\/adjunctive-lithium-effective-for-second-generation-antidepressants-tricyclics\/","title":{"rendered":"Adjunctive Lithium Effective for Second Generation Antidepressants, Tricyclics"},"content":{"rendered":"

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Antidepressant augmentation with lithium seems effective for both tricyclic antidepressants and second generation antidepressants, according to a recent systematic review and meta-analysis published in the online\u00a0Journal of Affective Disorders.<\/em><\/p>\n

While previous research on lithium augmentation focused mostly on tricyclic antidepressants, this meta-analysis covered lithium augmentation with tricyclic antidepressants as well as second generation antidepressants. Some 237 patients with unipolar major depression were involved in the meta-analysis\u2019 nine randomized, placebo-controlled trials.<\/p>\n

Overall, the odds ratio for lithium compared with placebo was 2.89, researchers reported.\u00a0Side effects were rare and were no more frequent with lithium than placebo.\u00a0<\/span><\/p>\n

\u201cDespite its efficacy,\u201d the authors noted, \u201cuse of lithium augmentation remains infrequent.\u201d<\/p>\n

The meta-analysis\u2019 limitations included small study sizes and limited data for patients who were resistant to treatment, researchers reported.<\/p>\n

\u2014Jolynn Tumolo<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Antidepressant augmentation with lithium seems effective for both tricyclic antidepressants and second generation antidepressants, according to a recent systematic review and meta-analysis published in the online\u00a0Journal of Affective Disorders. While previous research on lithium augmentation focused mostly on tricyclic antidepressants, this meta-analysis covered lithium augmentation with tricyclic antidepressants as well as second generation antidepressants. Some […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1419],"tags":[],"class_list":["post-4964","post","type-post","status-publish","format-standard","hentry","category-short-updates","entry"],"_links":{"self":[{"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/posts\/4964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/comments?post=4964"}],"version-history":[{"count":1,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/posts\/4964\/revisions"}],"predecessor-version":[{"id":4965,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/posts\/4964\/revisions\/4965"}],"wp:attachment":[{"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/media?parent=4964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/categories?post=4964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/tags?post=4964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}