{"id":7796,"date":"2016-12-03T10:57:15","date_gmt":"2016-12-03T07:57:15","guid":{"rendered":"http:\/\/seragpsych.com\/wordpress\/?p=7796"},"modified":"2016-12-03T10:57:15","modified_gmt":"2016-12-03T07:57:15","slug":"olanzapine-zyprexa","status":"publish","type":"post","link":"https:\/\/seragpsych.com\/wordpress\/olanzapine-zyprexa\/","title":{"rendered":"Olanzapine (Zyprexa\u00ae)"},"content":{"rendered":"
\n

<\/h1>\n<\/header>\n
\n

Olanzapine (US brand name Zyprexa\u00ae and generic) is a second-generation (atypical) antipsychotic. Here is basic information about this medication.<\/p>\n

FDA-approved indications<\/h4>\n

1. As oral formulation for:<\/em><\/p>\n

a. Schizophrenia in adults and adolescents<\/p>\n

b. Manic or mixed episodes associated with bipolar I disorder in adults and adolescents (ages 13-17 )<\/p>\n

c. Manic or mixed episodes associated with bipolar I disorder in adults (as an adjunct to valproate or lithium)<\/p>\n

2.\u00a0As Intramuscular injection for:<\/em><\/p>\n

Acute agitation associated with schizophrenia and bipolar I mania in adults<\/p>\n

3. Olanzapine in combination\u00a0with fluoxetine for:<\/em><\/p>\n

a. Depressive episodes associated with bipolar I disorder in adults<\/p>\n

b. Depressive episodes associated with bipolar I disorder in children and adolescents (ages 10-17)<\/p>\n

c. Treatment-resistant depression in adults<\/p>\n

Note:\u00a0Olanzapine is not approved for the treatment of dementia-related psychosis in elderly due to increased risk of death and cerebrovascular accidents.<\/p>\n

Dosage<\/h4>\n

1. Schizophrenia (adults)<\/em><\/p>\n

Start at 5\u201310 mg orally once daily orally<\/p>\n

Target: 10 mg\/day within several days<\/p>\n

2. Schizophrenia (adolescents)<\/em><\/p>\n

Start at 2.5\u20135 mg orally once daily<\/p>\n

Target: 10 mg\/day<\/p>\n

3. Bipolar I disorder (manic or mixed episodes) in adults<\/em><\/p>\n

Start at 10 or 15 mg orally once daily<\/p>\n

4. Bipolar I disorder (manic or mixed episodes) in adolescents<\/em><\/p>\n

Start at 2.5\u20135 mg orally once daily<\/p>\n

Target: 10 mg\/day<\/p>\n

5. Bipolar I disorder (manic or mixed episodes) with lithium or valproate in adults<\/em><\/p>\n

Start at 10 mg orally once daily<\/p>\n

6. Agitation associated with schizophrenia and bipolar I mania in adults<\/em><\/p>\n

10 mg Intramuscular (IM) injection\u00a0(5 mg or 7.5 mg when clinically warranted).<\/p>\n

Assess for orthostatic hypotension prior to subsequent dosing (max. 3 doses 2-4 hrs apart)<\/p>\n

7. Depressive episodes associated with bipolar I disorder in adults <\/em>(in combination with fluoxetine)<\/p>\n

Start at 5 mg of oral olanzapine and 20 mg of fluoxetine orally once daily<\/p>\n

8. Depressive episodes associated with bipolar I disorder in children and adolescents <\/em>(in combination with fluoxetine)<\/p>\n

Start at 2.5 mg of oral olanzapine and 20 mg of fluoxetine orally once daily<\/p>\n

9. Treatment resistant depression in adults <\/em>(in combination with fluoxetine)<\/p>\n

Start at 5 mg of oral olanzapine and 20 mg of fluoxetine orally once daily<\/p>\n

General Instructions (from Prescribing Information)<\/p>\n

1. Lower starting dose is\u00a0recommended in debilitated or pharmacodynamically sensitive patients or patients with predisposition to hypotensive reactions, or with potential for slowed metabolism.<\/p>\n

2. Olanzapine may be given without regard to meals.<\/p>\n

Olanzapine and Fluoxetine in combination<\/p>\n

1. Dosage adjustments, if indicated, should be made with the individual components according to efficacy and tolerability.<\/p>\n

2. Olanzapine monotherapy is not indicated for the treatment of depressive episodes associated with bipolar I disorder or treatment resistant depression.<\/p>\n

3. Safety of co-administration of doses above 18 mg olanzapine with 75 mg fluoxetine has not been evaluated.<\/p>\n

4. 50 mg fluoxetine has not been evaluated in children and adolescents ages 10 to 17.<\/p>\n

Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.<\/p>\n

Dosage forms and strengths<\/h4>\n

Tablets (Zyprexa\u00ae and generic): 2.5, 5, 7.5, 10, 15, 20 mg<\/p>\n

Orally disintegrating tablets (Zyprexa Zydis\u00ae and generic): 5, 10, 15, 20 mg<\/p>\n

Intramuscular injection (Zyprexa\u00ae and generic): 10 mg vial<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Olanzapine (US brand name Zyprexa\u00ae and generic) is a second-generation (atypical) antipsychotic. Here is basic information about this medication. FDA-approved indications 1. As oral formulation for: a. Schizophrenia in adults and adolescents b. Manic or mixed episodes associated with bipolar I disorder in adults and adolescents (ages 13-17 ) c. Manic or mixed episodes associated […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,458,151],"tags":[],"class_list":["post-7796","post","type-post","status-publish","format-standard","hentry","category-152","category-458","category-151","entry"],"_links":{"self":[{"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/posts\/7796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/comments?post=7796"}],"version-history":[{"count":1,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/posts\/7796\/revisions"}],"predecessor-version":[{"id":7812,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/posts\/7796\/revisions\/7812"}],"wp:attachment":[{"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/media?parent=7796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/categories?post=7796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/seragpsych.com\/wordpress\/wp-json\/wp\/v2\/tags?post=7796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}