Modafinil (US brand name Provigil® and generic) is a wakefulness promoting agent. Here is key information about this medication.

FDA-approved indications

To improve wakefulness in adult patients with narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD)

Dosage

1. Adults

Narcolepsy or OSA: 200 mg once daily in the morning

Shift work disorder: 200 mg once a day taken approximately one hour prior to start of the work shift

2. Geriatric patients

Consider lower dose

3. Patients with severe hepatic impairment

Reduce to half the recommended dose

Dosage forms and strengths

Tablets: 100 mg and 200 mg (scored)

Please refer to Prescribing Information (see link below) for complete discussion of dosage, administration, warnings and precautions, contraindications, etc.

Cytochrome P450 drug interactions

Modafinil is an inhibitor of CYP 2C19.

It is also an inducer of CYP 1A2 and CYP 3A4